• br In their Comment on the use of

  2019-05-17

  

  In their Comment on the use of antenatal corticosteroids to reduce preterm infant deaths, Kishwar Azad and Anthony Costello advise “extreme caution” before scale-up in low-income settings. They emphasise maternal sepsis as a concern but cite only one trial in which dexamethasone resulted in a sign

• While a large number of clinical trials have been completed

  2019-05-16

  

  While a large number of clinical trials have been completed or underway, there is a lack of strong evidence of their effectiveness and safety. Some experts pointed out that autologous transplantation may put patients at a risk of receiving the genetically defective immune cells, while allogeneic tra

• Early recognition of ICD lead malfunction is desirable to

  2019-05-16

  

  Early recognition of ICD lead malfunction is desirable to prevent the life-threatening consequences of lead failure. Recent reports indicate that the majority of patients with ICD lead failure experience inappropriate ICD therapies, often as the presenting problem [4,6]. Regular device interrogation

• br In an age when everything from sparrows to

  2019-05-16

  

  In an age when everything from sparrows to toilets has its own international day (March 20 and November 19, respectively, in case you were wondering), it\'s perhaps no surprise that the scholarly publishing matrix metalloproteinases has got in on the act. This week is . Organised by representati

• Causative genes for ARVC and their

  2019-05-16

  

  Causative genes for ARVC and their respective characteristics are summarized in Table 1. Desmosome genes for ARVC Other causative genes for ARVC Although more than half of ARVC patients carry mutations in desmosome genes, other genes have also been reported as causative genes for ARVC (Table

• br The estimated number of

  2019-05-16

  

  The estimated number of women who die each year from causes related to pregnancy or childbirth has dropped substantially—from 543 000 deaths in 1990 to about 287 000 in 2010. Nevertheless, maternal mortality ratios remain among the least equitable of all health indicators, ranging from less than f

• The launches in London and Boston

  2019-05-16

  

  The launches in London and Boston were just that; the beginning of an education and advocacy campaign intended to highlight the pivotal role of surgical care in health system strengthening. The formal Commission report, 32 000 words of synthesis, analysis, recommendations, and indicators, is only on

• Delegates emphasised the urgent need for a consensus regardi

  2019-05-16

  

  Delegates emphasised the urgent need for a consensus regarding the standards and guidelines among stakeholders in Kenya and Uganda. In addition, a common interpretation of the legal environment was considered crucial, and therefore the constitution and penal code would need to be harmonised in both

• This patient presented to our emergency department with

  2019-05-16

  

  This patient presented to our emergency department with a three-day history of worsening headache six years after she was diagnosed with mixed adenoneuroendocrine carcinoma of the uterine cervix. Upon presentation, she reported rapidly progressive dizziness, vomiting and rightward deviation when wal

• Adhesive interactions Adhesive interactions between myeloma

  2019-05-16

  

  Adhesive interactions: Adhesive interactions between myeloma ON-01910 and stromal cells play a significant role in both the homing of MM cells to the bone marrow and augmentation of the bone destructive process. These adhesive interactions result in activation of NF-κB and p38 MAP-kinase signaling,

• br Outstanding questions br Conflict

  2019-05-16

  

  Outstanding questions Conflict of interest Acknowledgments This work was supported by the Dutch Cancer SocietyUL2015-7599 KWF (EZ). Platelets and cancer metastasis Blood platelets play a primary role in wound healing and hemostasis. Since the first observation made (on himself) by the s

• Bernardo Ar valo de Le n se ala

  2019-05-15

  

  Bernardo Arévalo de León señala que en Guatemala la dsn no alcanzó el nivel de desarrollo conceptual que tuvo en otros países como Chile, Brasil y Argentina. Del mismo modo, el general Héctor Alejandro Gramajo Morales, un teórico de la dsn en Guatemala, indicó que si bien el concepto de seguridad na

• The reduction in mother to child transmission MTCT of HIV

  2019-05-15

  

  The reduction in mother-to-child transmission (MTCT) of HIV is one of the greatest success stories of the antiretroviral therapy (ART) era. However, evidence is accumulating that, despite avoiding HIV, HIV-exposed uninfected (HEU) infants have more infectious morbidity and mortality than HIV-unexpos

• There are several limitations to the

  2019-05-15

  

  There are several limitations to the procedure described herein. The present GC was developed for engaging the coronary sinus via a right-sided approach. However, this GC was bent dorsally and had the shortest tip and most acute tip angle among the Attain™ family, which facilitated its placement int

• It is established that hypoxia can induce autophagy

  2019-05-15

  

  It is established that hypoxia can induce autophagy [32,34–37]. We evidenced the autophagic activation in the cultured human osteosarcoma MG-63 mth1 pathway after incubation in 1% O2 for 24h. The concomitantly elevated LC3 protein levels with HIF-1α high expression on OS tissue sections also indicat

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